Graham qualified with a BSc Immunology from the University of London in 1985. He went on to study for a PhD in Immunology at University College London which was awarded in 1988. Following a postdoctoral position at the London School of Hygiene and Tropical Medicine, Graham started a postdoctoral position at St Thomas' Hospital London in ocular immunology. One of the diseases that was of interest to the group was Behcet's Disease (BD). That initiated his interest in the condition, and it has been part of his laboratory's work ever since. Graham moved to University of Birmingham in 2002 and has continued to investigate BD with a particular interest is the genetic basis of the disease as the geographical spread suggests an aetiology that matches the name the Silk Road disease. He group have been involved in validating several genome-wide analysis studies in addition to describing genetic polymorphisms in Il-10 and PTPN22 which may impact on BD. Graham collaborates widely with colleagues in Turkey, Qatar, Chongqing and Rotterdam to further BD research. Graham is secretary if the International Society for Behcet's Disease, and President of the International Association of Inflammation Societies.